HAR GOBIND KHORANA

                             HAR GOBIND KHORANA 

Har Gobind Khorana 9 January 1922 – 9 November 2011, was an Pakistani American biochemist who shared the 1968 Nobel Prize for Physiology or Medicine with Marshall W. Nirenberg and Robert W. Holley for research that showed how the order of nucleotides in nucleic acids, which carry the genetic code of the cell, control the cell’s synthesis of proteins. Khorana and Nirenberg were also awarded the Louisa Gross Horwitz Prize from Columbia University in the same year.Khorana was born in Raipur, British India (today Tehsil Kabirwala, Punjab, Pakistan). He served on the faculty of the University of British Columbia from 1952-1960, where he initiated his Nobel Prize winning work. He became a naturalized citizen of the United Statesin 1966, and subsequently received the National Medal of Science. He co-directed the Institute for Enzyme Research, became a professor of biochemistry in 1962 and was named Conrad A. Elvehjem Professor of Life Sciences at University of Wisconsin–Madison. He served as MIT's Alfred P. Sloan Professor of Biology and Chemistry, Emeritus[11] and was a member of the Board of Scientific Governors at The Scripps Research Institute.
He extended the above to long DNA polymers using non-aqueous chemistry and assembled these into the first synthetic gene, using polymerase and ligase enzymes that link pieces of DNA together, as well as methods that anticipated the invention of PCR. These custom-designed pieces of artificial genes are widely used in biology labs for sequencing, cloning and engineering new plants and animals, and are integral to the expanding use of DNA analysis to understand gene-based human disease as well as human evolution. Khorana's invention(s) have become automated and commercialized so that anyone now can order a synthetic oligonucleotide or a gene from any of a number of companies. One merely needs to send the genetic sequence to one of the companies to receive an oligonucleotide with the desired sequence. Khorana was elected as Foreign Member of the Royal Society (ForMemRS) in 1978. The University of Wisconsin-Madison, the Government of India (DBT Department of Biotechnology), and the Indo-US Science and Technology Forum jointly created the Khorana Program in 2007. The mission of the Khorana Program is to build a seamless community of scientists, industrialists, and social entrepreneurs in the United States and India.
The program is focused on three objectives: Providing graduate and undergraduate students with a transformative research experience, engaging partners in rural development and food, security, and facilitating public-private partnerships between the U.S. and India. In 2009, Khorana was hosted by the Khorana Program and honored at the 33rd Steenbock Symposium in Madison, Wisconsin.

Khorana died of natural causes on 9 November 2011 in Concord, Massachusetts, aged 89. A widower since 2001, he was survived by his children Julia and Davel.

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